Koppula P, Zhang Y, Zhuang L, Gan B (2018) Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer.
įotiadis D, Kanai Y, Palacín M (2013) The SLC3 and SLC7 families of amino acid transporters. Liang C, Zhang X, Yang M, Dong X (2019) Recent progress in ferroptosis inducers for cancer therapy. įearnhead HO, Vandenabeele P, Vanden Berghe T (2017) How do we fit ferroptosis in the family of regulated cell death? Cell Death Differ 24(12):1991–1998. The spotlight on this approach to cancer treatment is creating a new horizon and pointing to future opportunities.ĭixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Here, we elaborate on the mediation of ferroptosis by suppressing system Xc − and the relevant underlying molecular mechanism in cancer cells. Therefore, system Xc − inhibition may enhance chemotherapy sensitivity and optimize patient prognosis. xCT might serve as a novel biomarker, and its upregulation almost always indicates drug tolerance and poor survival. The overexpression of system Xc −, especially its core subunit xCT, has been reported in several tumors, and these high expression levels were closely related to cancer cell proliferation, invasion, metastasis and the tumor microenvironment. System Xc − (a cystine/glutamate antiporter system) is a promising target in cancer cells for ferroptosis induction. Cancer cells tend to modulate their redox state to prevent excessive peroxidation, eventually facilitating tumor growth. This novel cell death modality has been implicated in preventing cancer progression. Note: We do not offer technical support for developing or debugging scripted downloading processes.Ferroptosis is a type of oxidative stress-dependent regulated necrosis characterized by excessive lipid peroxide accumulation. Note that this policy may change as the SEC manages SEC.gov to ensure that the website performs efficiently and remains available to all users. This SEC practice is designed to limit excessive automated searches on SEC.gov and is not intended or expected to impact individuals browsing the SEC.gov website. Once the rate of requests has dropped below the threshold for 10 minutes, the user may resume accessing content on SEC.gov. If a user or application submits more than 10 requests per second, further requests from the IP address(es) may be limited for a brief period. Current guidelines limit users to a total of no more than 10 requests per second, regardless of the number of machines used to submit requests. We reserve the right to block IP addresses that submit excessive requests. To ensure our website performs well for all users, the SEC monitors the frequency of requests for SEC.gov content to ensure automated searches do not impact the ability of others to access SEC.gov content. Unauthorized attempts to upload information and/or change information on any portion of this site are strictly prohibited and are subject to prosecution under the Computer Fraud and Abuse Act of 1986 and the National Information Infrastructure Protection Act of 1996 (see Title 18 U.S.C. For security purposes, and to ensure that the public service remains available to users, this government computer system employs programs to monitor network traffic to identify unauthorized attempts to upload or change information or to otherwise cause damage, including attempts to deny service to users.
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#CW13 XCT 356 DOWNLOAD#
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